Resources
Insights from the path of discovery.
Perspectives on rare disease diagnosis, patient finding, and building trustworthy clinical decision support.
Finding clarity amidst complexity
The idea behind the Sagacity name, and why, after 25 years commercializing diagnostics, I believe the hard part isn't the science but connecting innovation to the patients who need it.
June 12, 2026 · Raymond Tarr
What commercializing diagnostics taught me about complexity
Twenty-five years bringing diagnostics to market taught me that the science is rarely the bottleneck. Reflections on adoption, trust, and why the best technology amplifies the people on the front line.
June 10, 2026
FHIR and real-world data: the foundation for finding patients
Why a standards-based, in-warehouse approach to FHIR and real-world clinical data is the right foundation for rare disease patient finding: no data migration, no PHI leaving your environment.
June 3, 2026
What to look for in a patient-finding platform
If you're evaluating a rare disease patient-finding platform, the demo is the easy part. Here are the questions that actually predict whether it will hold up, across reproducibility, governance, data security, and explainability.
May 27, 2026
Why rare disease definitions belong under governance, not in a prompt
If two runs of a patient-finding tool produce two different cohorts, you don't have a tool. You have a liability. How governed, KOL-validated disease definitions keep clinical decision support reproducible and defensible.
May 20, 2026
Patient finding is a partnership, not a transaction
The most durable work in rare disease happens when health systems, clinicians, and life-science partners share a goal, and a clear data boundary. How we think about building those partnerships.
May 13, 2026
Finding the undiagnosed: surfacing rare disease patients in EHR data
The evidence pointing to a rare disease diagnosis is often already in the chart. Here's how computational phenotyping over real-world EHR data finds the patients no one has connected yet.
May 6, 2026
The case for finding patients earlier
Earlier diagnosis isn't only kinder. For a growing number of rare diseases it changes outcomes, and it changes the economics of innovation. The strategic case for treating patient finding as a priority.
April 29, 2026
The rare disease diagnostic odyssey, by the numbers
Rare disease patients often wait years and see many specialists before an answer. Here's what the data says about the diagnostic odyssey, and where the delay actually comes from.
April 15, 2026