Resources
Insights from the path of discovery.
Perspectives on rare disease diagnosis, patient finding, and building trustworthy clinical decision support.
Finding clarity amidst complexity
The idea behind the Sagacity name, and why, after 25 years commercializing diagnostics, I believe the hard part isn't the science but connecting innovation to the patients who need it.
June 12, 2026 · Raymond Tarr
What commercializing diagnostics taught me about complexity
Twenty-five years bringing diagnostics to market taught me that the science is rarely the bottleneck. Reflections on adoption, trust, and why the best technology amplifies the people on the front line.
June 10, 2026
FHIR and real-world data: the foundation for finding patients
Why a standards-based, in-warehouse approach to FHIR and real-world data is the right foundation for rare disease patient finding: no migration, no PHI moved.
June 3, 2026
What to look for in a patient-finding platform
Evaluating a patient-finding platform? The demo is the easy part. The questions that reveal whether it holds up: reproducibility, governance, explainability.
May 27, 2026
Why rare disease definitions belong under governance, not in a prompt
If two runs of a patient-finding tool produce different cohorts, that's a liability, not a tool. How governed, KOL-validated definitions stay reproducible.
May 20, 2026
Patient finding is a partnership, not a transaction
The most durable work in rare disease happens when health systems, clinicians, and life-science partners share a goal, and a clear data boundary. How we think about building those partnerships.
May 13, 2026
Finding the undiagnosed: surfacing rare disease patients in EHR data
The evidence pointing to a rare disease diagnosis is often already in the chart. Here's how computational phenotyping over real-world EHR data finds the patients no one has connected yet.
May 6, 2026
The case for finding patients earlier
Earlier diagnosis isn't only kinder. For many rare diseases it changes outcomes and the economics of innovation. The strategic case for finding patients sooner.
April 29, 2026
The rare disease diagnostic odyssey, by the numbers
Rare disease patients wait years and see many specialists before an answer. What the data says about the diagnostic odyssey, and where the delay comes from.
April 15, 2026